期刊
SURGICAL ONCOLOGY-OXFORD
卷 9, 期 4, 页码 151-171出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0960-7404(01)00010-X
关键词
E-cadherin; catenin; breast cancer; metastasis
E-cadherin and its adhesion complex play an essential role in the adhesion of breast cancer cells and tissues. Members of the complex, such as beta -catenin, act as regulators on cell adhesion, and are involved in cell signalling and transcription regulation. The adhesion complex is a known structure in the control of tumour progression and metastasis. Recent years have seen a rapid expansion in the understanding of the biology and clinical relevance of the complex in breast cancer. The current article summarises recent progresses in the molecular/cellular biology of E-cadherin and its complex and the clinical, diagnostic, prognostic, and therapeutic value of this complex in breast cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.
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