期刊
JOURNAL OF HEPATOLOGY
卷 33, 期 6, 页码 998-1002出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-8278(00)80135-X
关键词
chronic hepatitis B; genotype; HBV DNA; hepatitis B virus; interferon; sustained response
Background/Aims: Possible pathogenic differences among hepatitis B virus (HBV) genotypes have been observed; however, the response to interferon therapy among HBV genotypes remains unknown. We therefore analyzed the efficacy of interferon alfa in the treatment of chronic hepatitis B patients with different HBV genotypes, Methods: Fifty-eight genotype B or C infected chronic hepatitis B patients who had been treated with interferon alfa-2b were retrospectively studied. The response to interferon was defined as normalization of serum aminotransferase level, loss of hepatitis B e antigen and HBV DNA 48 weeks post-treatment, Results: Baseline data of both groups of patients were comparable; however, genotype C patients had a higher serum aminotransferase level and a higher frequency of core promoter mutation, The response rate was 41% and 15% in genotype B and C patients, respectively (p=0.045), In those with higher serum aminotransferase levels, the response rate was 50% and 17%, respectively (p=0.025). Additionally, younger age and genotype B infection may predict a better response to interferon alfa, Conclusions: HBV genotype C, compared to genotype B, is associated with a higher frequency of core promoter mutation, and a lower response rate to interferon alfa therapy.
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