期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 120, 期 1-3, 页码 141-149出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0047-6374(00)00217-7
关键词
epitalon; ultralow concentrations; lifespan; Drosophila melanogaster
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva). Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations - from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females. The increase in LS did not depend on the substance dose. Effective concentrations of epitalon were 16 000-80 000 000 times lower than those of melatonin. The possible mechanisms of the antioxidant and regulatory effects of epitalon are discussed. (C) 2000 Published by Elsevier Science Ireland Ltd.
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