期刊
BIODRUGS
卷 27, 期 1, 页码 55-67出版社
ADIS INT LTD
DOI: 10.1007/s40259-012-0007-0
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资金
- Digestive Disease Research Center (DDRC) at Tehran University of Medical Sciences
- Research Center for Pharmaceutical Nanotechnology (RCPN) at Tabriz University of Medical Sciences
Background and Objective Gastric/gastrointestinal cancers are associated with high mortality worldwide. G-protein coupled receptor (GPCR) superfamily members such as gastrin/cholecystokinin-B receptor (CCK-BR) are involved in progression of gastric tumors, thus CCK-BR is considered as a potential target for immunotherapy. However, production of functional monoclonal antibodies (mAbs) against GPCR seems to be very challenging, in part due to its integration in cell membranes and inaccessibility for selection. To tackle this problem, we implemented phage display technology and a solution-phase biopanning (SPB) scheme for production of mAbs specific to the native conformation of CCK-BR.
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