期刊
JOURNAL OF IMMUNOLOGY
卷 165, 期 11, 页码 6381-6386出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.165.11.6381
关键词
-
类别
In this work, we have studied the role of the MHC class Ib molecules in the selection and maintenance of CD8(+) T splenocytes. We have compared the CD8(+) T fell repertoires of wild-type, H-2K-deficient, H-2D-deficient, or double knockout C57BL/6 mice, We show that the different CD8(+) repertoires,. selected either by class Ia and class nb or by class Tb molecules only, use the various V alpha (AV) and V beta (BV) rearrangements in the same proportion and without biases in the CDR3 size distribution. Furthermore, we have estimated the size of the BY repertoire in the four different strains of mice. Interestingly, we have found that the BV repertoire size is proportional to the overall number of CD8(+) splenocytes. This observation implies that BV diversity is positively correlated with the number of CD8(+) cells, even when the number of CD8(+) splenocytes is dramatically reduced (90% in the double knockout mice).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据