期刊
IMMUNOLOGY TODAY
卷 21, 期 12, 页码 611-614出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0167-5699(00)01745-X
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DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
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