期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 409, 期 1, 页码 37-43出版社
ELSEVIER
DOI: 10.1016/S0014-2999(00)00796-2
关键词
5-HT (5-hydroxytryptamine, serotonin); chronic pain; spinal cord; paw pressure test; (rat)
The present study examined the effects of intrathecal (i.t.) administration of 5-hydroxytryptamine (5-HT; 0.1-100 mug) on mechanical hyperalgesia associated with neuropathic pain (chronic constriction of the sciatic nerve model and diabetic model) and inflammatory pain (carrageenan and polyarthritic models) in rats. Results demonstrated that the hyperalgesia observed in the mononeuropathic and diabetic rats was attenuated by 5-HT; the active dose, however, was 100- to 1000-fold higher than that required in normal rats, and was moderately effective. In the two experimental models of inflammatory pain, 5-HT was not markedly or similarly active. In the carrageenan model, 5-HT at the highest dose was only weakly effective whereas in the polyarthritic model it was inactive. Together, these results show that 5-HT has antinociceptive effects in several rat pain models, except in the model of diffuse pain (polyarthritic rats). Its antinociceptive effects in these models, however, are slight and differ from those observed in normal rats. (C) 2000 Elsevier Science B.V. All rights reserved.
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