期刊
JOURNAL OF NEUROSURGERY
卷 93, 期 6, 页码 932-939出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/jns.2000.93.6.0932
关键词
glioblastoma; astrocytoma; tumor incidence
资金
- NCI NIH HHS [T-32 CA 09581-010] Funding Source: Medline
Object. In this study the authors describe secular trends in the incidence of three glial tumors-glioblastoma multiforme (GBM), astrocytoma not otherwise specified (ANOS), and anaplastic astrocytoma (AA)-in New York state from 1976 through 1995. They also describe the effect of age and sex on the relative risk (RR) for these tumors, specifically GEM. Methods. Crude, age-, and sex-specific incidence rates were calculated for each tumor type from 1976 to 1995 by using data from the New York State Cancer Registry. Age-adjusted incidence rates were calculated by the direct standardization procedure, in which the 1970 United States Census Population Standard Million is used. The RR of GEM for the female population was calculated and plotted. Statistical comparisons were made using Pearson's correlation coefficient and regression analysis with the coefficient of variation. Conclusions. The age-adjusted incidence of these three glial tumors increased during the study period. Increases in age-specific incidence of GEM were primarily limited to patients 60 years of age or older. The reasons for these increases cannot be fully explained with the data. Those in the female population had a lower risk of developing these tumors than those in the male. For GEM, the protective effect of sex was first evident at the approximate age of menarche, was greatest at the approximate age of menopause, and decreased in postmenopausal age strata. The overall protective effect of female sex and the described trend in RR for GEM in the female population suggests that sex hormones and/or genetic differences between males and females may play a role in the pathogenesis of this tumor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据