期刊
NEUROPSYCHOPHARMACOLOGY
卷 23, 期 6, 页码 601-622出版社
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(00)00161-5
关键词
5-HT; serotonin; tryptophan-free drink; major depression
资金
- NCRR NIH HHS [MOI RR00827] Funding Source: Medline
- NIMH NIH HHS [MH 18825, MH 57134-01] Funding Source: Medline
We review here the rapid tryptophan depletion (RTD) methodology and its controversial associated with depressive relapse. RTD has been used over the past decade to deplete serotonin (5-hydroxy-tryptamine, or 5-HT) in humans and to probe the role of the central serotonin system in a variety of psychiatric conditions. Its current popularity was simulated by reports that RTD reversed the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs) im remitted patients with a history of depression but not in patients treated with antidepressants which promote catecholaminergic rather than serotonergic neurotransmission (such as tricyclic antidepressants or buproprion). However, RTD has inconsistent effects in terms of full clinical relapse in depressed patients. Pooling the data from all published reports, patients who are either unmediated and/or fully remitted are much less likely to experience relapse (7 of 61, or similar to9%) than patients who are recently mediated and partially remitted (63 of 133, or similar to 47%; although, the numbers here may reflect patient overlap between reports). Recently remitted patients who have been treated with non-pharmacological therapies such as total sleep deprivation, electroconvulsive therapy, or bright light therapy also do not commonly show full clinical relapse with RTD. We briefly review RTD effects in other psyhiatric disorders, many of which are treated with SSRIs. There is accumulating evidence to suggest that RTD affects central serotonergic neurotransmission. Nevertheless, many questions remain about the ability of RTD to reverse the beneficial effects of SSRIs or MAOIs, or to induce symptoms in unmedicated symptomatic or asymptomatic patients. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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