期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 21, 期 12, 页码 469-474出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01559-5
关键词
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The recent development of a novel class of insulin-sensitizing drugs, the thiazolidinediones (TZDs), represents a significant advance in antidiabetic therapy. One key mechanism by which these drugs exert their effects is by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma), a member of the nuclear receptor family. Evidence supporting this mechanism of action of the TZDs will be reviewed in this article. Recent data suggests that PPAR-gamma agonists might also have therapeutic potential in the treatment of inflammatory diseases and certain cancers.
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