期刊
BRAIN TOPOGRAPHY
卷 13, 期 2, 页码 79-96出版社
SPRINGER
DOI: 10.1023/A:1026683200895
关键词
EEG; ERP; fMRI; PET; co-registration; generators; current sources; dipole localization
A two-scale theoretical description outlines relationships between brain current sources and the resulting extracranial electric field, recorded as EEG. Finding unknown sources of BEG, the so-called inverse problem, is discussed in general terms, with emphasis on the fundamental non-uniqueness of inverse solutions. Hemodynamic signatures, measured with fMRI, are expressed as voxel integrals to facilitate comparisons with EEG. Two generally distinct cell groups (1 and 2), generating EEG and fMRI signals respectively, are embedded within the much broader class of synaptic action fields. Cell groups 1 and 2 may or may not overlap in specific experiments. Implications of this incomplete overlap for co-registration studies art considered. Each experimental measure of brain function is generally sensitive to a different kind of source activity and to different spatial and temporal stales. Failure to appreciate such distinctions can exacerbate conflicting views of brain function that emphasize either global integration or functional localization.
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