期刊
MELANOMA RESEARCH
卷 10, 期 6, 页码 507-514出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008390-200012000-00001
关键词
aneuploidy; glycosylation; hybridization; macrophage; melanoma; metastasis
This article reviews a long-standing hypothesis that metastases might be initiated through the generation of hybrids between primary tumour cells and tumour-infiltrating leucocytes such as macrophages. In this concept the hybrids become metastatic through expression of the leucocyte motility phenotype. A history of the hybrid hypothesis is presented along with recent evidence on how macrophage x tumour cell hybridization could account for some of the most defining characteristics of metastatic cells: aneuploidy, enhanced motility, aberrant glycosylation and, particularly seen in melanoma, phenotypic diversity. (C) 2000 Lippincott Williams & Wilkins.
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