期刊
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
卷 26, 期 8, 页码 758-762出版社
W B SAUNDERS CO LTD
DOI: 10.1053/ejso.2000.0999
关键词
pathology; lymph node; upstaging; cancer; colon; rectum; dissection; prognosis; fixation; cut-up
Introduction: There is now evidence that meticulous specimen dissection may 'upstage' around one-quarter of colorectal cancers from node negative to node positive, although there is much debate as to how to achieve this: some authors prefer fat clearance techniques while others have opted for more conventional lymph-node retrieval with manual specimen 'breadknifing' and lymph-node palpation. While fat clearance is probably the optimum technique, it is time-consuming, costly and does not provide rapid diagnostic results. Methods: A prospective pathological study of 50 colorectal cancer resections was conducted with 100 comparison cases, the study group receiving at least an additional 24-h fixation of the mesocolonic or mesorectal fat in 10% aqueous formaldehyde prior to specimen dissection. Results: The percentage of node-negative colorectal cancer was significantly lower in the study group compared with the matched comparison group: (18) 36% compared with (55) 55% of comparison cases. Conclusions: Effective lymph-node retrieval techniques require mesocolic/mesorectal fat to be adequately fixed prior to pathological dissection. This study suggests that satisfactory lymph-node retrieval is possible without fat clearance, provided the mesenteric fat is suitably fixed prior to colorectal cancer specimen dissection. (C) 2000 Harcourt Publishers Ltd.
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