期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 12, 页码 6803-6811出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b00181
关键词
hydrogel nano composites; self-folding bilayers; drug delivery; magnetic manipulation; microrobotics
资金
- European Research Council Advanced Grant Microrobotics and Nanomedicine (BOTMED)
- ERC [247283]
- Swiss National Science Foundation
- National Institute of Health [R01 DE0013349]
- Generalitat de Catalunya [2014-SGR-1015]
- MINECO [RYC-2012-10839]
- Swiss National Science Foundation [200020-146176]
- European Research Council, under the European Union's Seventh Framework Programme (FP7, ERC) [247283]
- Onassis Foundation
- ICREA Funding Source: Custom
- Swiss National Science Foundation (SNF) [200020_146176] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [247283] Funding Source: European Research Council (ERC)
The effect of dynamic shape switching of hydrogel bilayers on the performance of self-folding microrobots is investigated for navigation in body orifices and drug release on demand. Tubular microrobots are fabricated by coupling a thermoresponsive hydrogel nanocomposite with a poly(ethylene glycol)diacrylate (PEGDA) layer, to achieve spontaneous and reversible folding from a planar rectangular structure. Graphene oxide (GO) or silica-coated superparamagnetic iron oxide nanoparticles are dispersed in the thermoresponsive hydrogel matrix to provide near-infrared (NIR) light sensitivity or magnetic actuation, respectively. The NIR light-responsive microstructures are fabricated for triggered drug delivery while magnetic nanocomposite-based microrobots are used to analyze the role of shape in locomotion. Experimental analysis and computational simulations of tubular structures show that drug release and motility can be optimized through controlled shape change. These concepts are finally applied to helical microrobots to show a possible way to achieve autonomous behavior.
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