期刊
NATURE NEUROSCIENCE
卷 3, 期 12, 页码 1301-1306出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/81834
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资金
- NIA NIH HHS [P30AG10133] Funding Source: Medline
- NINDS NIH HHS [NS33779, NS38399] Funding Source: Medline
The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha -synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.
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