期刊
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH
卷 30, 期 4, 页码 191-196出版社
SPRINGER-VERLAG
DOI: 10.1007/s005990070006
关键词
bovine seminal ribonuclease; lymphocytes; phytohemagglutinin; apoptosis
Bovine seminal ribonuclease is a member of the RISBAses (ribonucleases with special biological actions) family. It exerts specific anti-tumor, embryotoxic, aspermatogenic and immunosuppressive activities. The cytotoxic effect of bovine seminal ribonuclease on tumor cells is accompanied by the induction of apoptosis. We provide ultrastructural and flow cytometry evidence of apoptotic death following bovine seminal ribonuclease treatment, in normal cells and phytohemagglutinin-stimulated lymphocytes. Transmission and scanning electron microscopy, which were fully supported by flow cytometry data, showed typical features of apoptosis, such as decreased cell size, chromatin condensation, fragmentation in micronuclei, and the presence of apoptotic bodies.
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