期刊
ANALYST
卷 140, 期 21, 页码 7062-7081出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00780a
关键词
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资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) [R21AI107415]
- National Institute of General Medical Sciences of the NIH [SC2GM105584]
- IDR Program at the University of Texas at El Paso (UTEP)
- NIH RCMI Pilot Grant
- Key (Key grant) Project of Chinese Ministry of Education [313045]
- International Science & Technology Cooperation Program of China [2013DFG02930]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI107415] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [SC2GM105584] Funding Source: NIH RePORTER
Early and timely detection of disease biomarkers can prevent the spread of infectious diseases, and drastically decrease the death rate of people suffering from different diseases such as cancer and infectious diseases. Because conventional diagnostic methods have limited application in low-resource settings due to the use of bulky and expensive instrumentation, simple and low-cost point-of-care diagnostic devices for timely and early biomarker diagnosis is the need of the hour, especially in rural areas and developing nations. The microfluidics technology possesses remarkable features for simple, low-cost, and rapid disease diagnosis. There have been significant advances in the development of microfluidic platforms for biomarker detection of diseases. This article reviews recent advances in biomarker detection using cost-effective microfluidic devices for disease diagnosis, with the emphasis on infectious disease and cancer diagnosis in low-resource settings. This review first introduces different microfluidic platforms (e.g. polymer and paper-based microfluidics) used for disease diagnosis, with a brief description of their common fabrication techniques. Then, it highlights various detection strategies for disease biomarker detection using microfluidic platforms, including colorimetric, fluorescence, chemiluminescence, electrochemiluminescence (ECL), and electrochemical detection. Finally, it discusses the current limitations of microfluidic devices for disease biomarker detection and future prospects.
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