期刊
PHYSICAL REVIEW E
卷 62, 期 6, 页码 8413-8419出版社
AMERICAN PHYSICAL SOC
DOI: 10.1103/PhysRevE.62.8413
关键词
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Intrinsic noise and random synaptic inputs generate a fluctuating current across neuron membranes. We determine the statistics of the output spike train of a biophysical model neuron as a function of the mean and variance of the fluctuating current, when the current is white noise, or when it derives from Poisson trains of excitatory and inhibitory postsynaptic conductances. In the first case, the firing rate increases with increasing Variance of the current, whereas in the latter case it decreases. In contrast, the firing rate is independent of variance (for constant mean) in the commonly used random walk, and perfect integrate-and-fire models for spike generation. The model neuron can be in the current-dominated state, representative of neurons in the in vitro slice preparation, or in the fluctuation-dominate state, representative of in vivo neurons. We discuss the functional relevance of these states to cortical information processing.
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