期刊
EXPERIMENTAL GERONTOLOGY
卷 35, 期 9-10, 页码 1229-1237出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0531-5565(00)00191-1
关键词
circadian rhythms; aging; sleep; dementia; Alzheimer's disease
The incidence of disturbed sleep is strongly increased in healthy and demented elderly. Age-related alterations in the circadian timing system appear to contribute strongly to these problems. With increasing age, a lack of input to the suprachiasmatic nucleus (SCN), the biological clock of the brain, may accelerate de-activation of neurons involved in the generation of 24-h rhythm or output of this rhythm. This process appears to be reversible, since supplementation of stimuli that impinge on the SCN can re-activate these neurons and ameliorate disturbances in the sleep-wake rhythm. (C) 2000 Elsevier Science Inc. All rights reserved.
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