期刊
ANALYST
卷 140, 期 21, 页码 7146-7149出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an01573a
关键词
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资金
- Fundamental Research Funds for the Central Universities [2014ZB0002]
- Opening Project of Guangdong Provincial Key Laboratory of New Drug Design and Evaluation [2011A060901014]
A colorimetric and red-emitting fluorescent dual probe for G-quadruplexes was devised with a conjugated coumarin-benzothiazole scaffold. Its significant and distinct changes in both color and fluorescence enable the label-free and visual detection of G-quadruplex structures. In addition, this probe gives a distinct strong emission response to the nucleoli in fixed cells imaging, which might be attributed to the interaction between the probe and rDNA G-quadruplex based on the chromatin immunoprecipitation assay. All these results suggest its promising application prospects in the G-quadruplex research field.
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