期刊
MOLECULAR CELL
卷 6, 期 6, 页码 1287-1295出版社
CELL PRESS
DOI: 10.1016/S1097-2765(00)00127-1
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资金
- NICHD NIH HHS [R01 HD036655] Funding Source: Medline
Mammalian SWI/SNF complexes utilize either brahma (Brm) or brahma-related gene 1 (Brg1) catalytic subunits to remodel nucleosomes in an ATP-dependent manner, arm was previously shown to be dispensable, suggesting that arm and Brg1 are functionally redundant. To test this hypothesis, we have generated a Brg1 null mutation by gene targeting, and, surprisingly, homozygotes die during the periimplantation stage. Furthermore, blastocyst outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives. However, experiments with other cell types demonstrate that Brg1 is not a general cell survival factor. In addition, Brg1 heterozygotes are predisposed to exencephaly and tumors. These results provide evidence that biochemically similar chromatin-remodeling complexes have dramatically different functions during mammalian development.
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