期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 10, 期 23, 页码 2625-2627出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00534-5
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HIV protease inhibitors containing 6-hydroxy-1,3-dioxin-4-one ring system as a new scaffold have been prepared. Among them, compound 4d showed potent HIV protease inhibitory activity (IC(50) = 0.01 muM) and antiviral activity in cell culture (EC(50) = 0.96 muM, SI = 65.69). (C) 2000 Elsevier Science Ltd. All rights reserved.
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