期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 25, 页码 13812-13817出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.240469997
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资金
- NIAID NIH HHS [R21AI44735] Funding Source: Medline
To test the hypothesis that beta -chemokine levels may be relevant to the control of HN in vivo, we compared RANTES, MIP-1 alpha, and MIP-1 beta production from purified CD8(+) T cells from 81 HIV-infected subjects and from 28 uninfected donors. Asymptomatic HIV+ subjects produced significantly higher levels of MIP-1 alpha and MIP-1 beta, but not RANTES, than uninfected donors or patients that progressed to AIDS. In contrast, beta chemokines in plasma were either nondetectable or showed no correlation with clinical status. The high beta -chemokine-mediated anti-HIV activity was against the macrophage tropic isolate HIV-1(BAL), with no demonstrable effect on the replication of the T-cell tropic HIV-1(IIIB) These findings suggest that constitutive beta -chemokine production may play an important role in the outcome of HIV-1 infection.
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