期刊
BIOCONJUGATE CHEMISTRY
卷 23, 期 9, 页码 1726-1730出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc300214z
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资金
- Natural Science and Engineering Research Council of Canada
- Canadian Institute of Cancer Research
- Canadian Foundation for Innovation
- Princess Margaret Hospital Foundation
- Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research
A porphyrin-phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin-lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SEAS based imaging.
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