期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 4, 页码 664-672出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc100448r
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- CNR
- Comune di Milano [55/2008]
Integrin alpha(v)beta(3) is an adhesion molecule involved in physiological and pathological angiogenesis as well as. tumor invasion and metastasis. Therefore, it is considered an important target for molecular imaging and delivery of therapeutics for cancer, and there is a strong interest in developing novel agents interacting with this protein. Nevertheless, the interaction of individual ligands is often still weak for efficient tumor targeting, and many research groups have synthesized multivalent displays in order to overcome this problem. Gold nanoparticles can be considered a smart platform for polyvalent presentation on account of their globular shape, tunable size, facile surface chemistry, and biocompatibility. Moreover, their unique physical properties render gold nanoparticles ideal candidates for tumor diagnosis and therapy. Here, we report the synthesis. and characterization Of gold nanoparticles functionalized with cRGD integrin ligand and their employment for targeting human cancer cells expressing alpha(v)beta(3) integrin.
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