期刊
CANCER LETTERS
卷 161, 期 1, 页码 17-26出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(00)00586-3
关键词
ovarian carcinoma; cdk-inhibitor p21(cip1); cisplatin; chemoresistance; apoptosis
类别
The seriousness of ovarian cancer, which is related to the observed link between recurrency and cell cycle control defect, prompted us to explore the effect of ectopic expression of the cdk inhibitor p21(cip1/waf1) on ovarian carcinoma chemosensitivity. The transfection of p21(cip1/waf1) cDNA into SKOV3 and OVCAR3 cells led to reduction of tumor cell growth, enhanced susceptibility to cisplatin-induced apoptosis, and abolition of recurrency after cisplatin exposure. p21(cip1/waf1) gene transfer allowed a marked reduction of the cisplatin concentration needed to erradicate the tumor cell population. These results suggest exploring the possible use of p21(cip1/waf1) as an adjunctive to conventional chemotherapy. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved.
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