期刊
VACCINE
卷 19, 期 -, 页码 S17-S25出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(00)00273-5
关键词
tubotympanum; otitis media pathogenesis; innate immunity
The sterility of the eustachian tube and tympanic cavity of normal individuals is maintained not only by the adaptive immune system, but also by the mucociliary system and the antimicrobial molecules of innate immunity. Mucin production and periciliary fluid homeostasis are essential for normal mucociliary function and dysfunction of this system is an important risk factor for otitis media. The secreted antimicrobial molecules of the tubotympanum include lysozyme, lactoferrin, beta defensins, and the surfactant proteins A and D (SP-A, SP-D). Defects in the expression or regulation of these molecules may also be the major risk factor for otitis media. (C) 2000 Elsevier Science Ltd. All rights reserved.
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