期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 11, 页码 2199-2209出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc200281k
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资金
- NSERC
- Alexander Graham Bell Canada Graduate Scholarship
The click chemistry era has generated a library of versatile spring-loaded reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that require high levels of precision and control, namely, materials that promote tissue regeneration such as hydrogels, 2D ftinctionalized substrates, and 3D biomimetic scaffolds. In this review, the synthesis and application of regenerative biomaterials via click chemistry are summarized. Particular emphasis is placed on the copper(I)-catalyzed alkyne-azide cycloaddition, Diels-Alder cycloadditions, and thiol-click coupling.
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