期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 6, 页码 1056-1065出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc100542r
关键词
-
类别
资金
- National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services [HHSN268201000043C]
- Frechet fund
- Deutsche Forschungsgemeinschaft (DFG)
- Alexander von Humboldt Foundation (AvH)
We report a new acid-sensitive, biocompatible, and biodegradable microparticulate delivery system, spermine modified acetalated-dextran (Spermine-Ac-DEX), which can be used to efficiently encapsulate siRNA. These particles demonstrated efficient gene knockdown in HeLa-luc cells with minimal toxicity. This knockdown was comparable to that obtained using Lipofectamine, a commercially available transfection reagent generally limited to in vitro use due to its high toxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据