期刊
CELL
卷 103, 期 6, 页码 885-896出版社
CELL PRESS
DOI: 10.1016/S0092-8674(00)00192-6
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资金
- NICHD NIH HHS [HD27262, HD07183] Funding Source: Medline
- NIGMS NIH HHS [GM07270] Funding Source: Medline
The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta -catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta -catenin bound to the beta -catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta -catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta -catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.
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