期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 5, 页码 859-864出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc2000947
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资金
- KWF [PGF 2009-4344]
- Centre for Translational Molecular Medicine [030-104]
The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives, Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.
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