期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 4, 页码 546-550出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc100579d
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资金
- Alberta Ingenuity Centers Program
- NIH [GM60938, AI16165]
We report the synthesis and in vitro evaluation of a multivalent homing device, a polymer which contains preordered pendant groups with dual specificity, a trisaccharide moiety, which is specific for the siglec CD22, and an antibody specific hapten, nitrophenol. The device efficiently attracts antihapten IgM to the surface of human lymphoma B cells as well as to CD22-conjugated magnetic beads by mediating the formation of a ternary complex on the surface of the target.
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