4.7 Article

The pathology of REM sleep behavior disorder with comorbid Lewy body dementia

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NEUROLOGY
卷 55, 期 11, 页码 1730-1732

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LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.55.11.1730

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  1. NIA NIH HHS [P50 AG008671, P50 AG08671] Funding Source: Medline

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A patient with REM sleep behavior disorder who subsequently developed probable Lewy body dementia is now reported to have a definite pathologic diagnosis of Lewy body dementia. Examination of brain revealed Lewy bodies as well as marked neuronal loss in brainstem monoaminergic nuclei-particularly locus coeruleus and substantia nigra-that inhibit cholinergic neurons in the pedunculopontine nucleus mediating atonia during REM sleep.

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