期刊
BIOCONJUGATE CHEMISTRY
卷 22, 期 12, 页码 2369-2376出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc200086c
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资金
- National Natural Science Foundation of China [90817101, 20905022, 20775023, 20865006]
- 973 National Basic Research Program of China [2007CB310500]
Identification and quantification of small organic molecules capable of binding to a protein of interest with reasonable affinity and specificity is a central problem. Via developing DNA-encoded recognizing probe, we validate a proof-of-principle for constructing of small target-to-DNA conversion that screens the small molecule-protein interaction. Successful identification of beta-indole acetic acid, abscisic acid, or 2,4-dichlorophenoxyacetic acid/corresponding antibody binding implies its fascinating potential for interrogating small molecule/protein interaction.
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