期刊
BIOCONJUGATE CHEMISTRY
卷 21, 期 4, 页码 715-722出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc900511j
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资金
- National Heart Lung and Blood Institute of the NIH [HL80711, HL080729]
- Center of Cancer Nanotechnology Excellence [CA 119338]
- National Cancer Institute [CA86307]
A novel nanoparticle-based dual-modality positron emission tomograph/magnetic resonance imaging (PET/MRI) contrast agent was developed. The probe consisted of a superparamagnetic iron oxide (SPIO) core coated with PEGylated phospholipids. The chelator 1,4,7,10-tetraazacyclo-dodecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to PEG termini to allow labeling with positron-emitting Cu-64. Radio labeling with Cu-64 at high yield and high purity was readily achieved. The (Cu-64-SPIO probes produced strong MR and PET signals and were stable in mouse serum for 24 h at 37 degrees C. Biodistribution and in vivo PET/CT imaging studies of the probes showed a circulation half-life of 143 min and high initial blood retention with moderate liver uptake, making them an attractive contrast agent for disease studies.
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