期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 45, 期 2-3, 页码 169-188出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(00)00114-9
关键词
liquid chromatography; capillary electrophoresis; electrochemical detection; fluorescence detection; mass spectrometry; biosensor
资金
- NCI NIH HHS [5T32 CA09242-20] Funding Source: Medline
- NHLBI NIH HHS [HL-34193] Funding Source: Medline
- NIGMS NIH HHS [R43-GM52272, R01 GM044900-11] Funding Source: Medline
Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the analytical system. Rapid separations can be coupled on-line with microdialysis to provide near real-time data. By combining microdialysis sampling with a liquid chromatographic or capillary electrophoretic separation and a highly sensitive detection method, a separation-based sensor can be developed. Such sensors have been applied to the investigation of drag entities as well as to study endogenous analytes. (C) 2000 Published by Elsevier Science B.V.
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