期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 384, 期 2, 页码 205-215出版社
ELSEVIER SCIENCE INC
DOI: 10.1006/abbi.2000.2131
关键词
connexin; gap junction; phosphorylation; v-Src; MAP kinase; PKC
资金
- NCI NIH HHS [CA52098] Funding Source: Medline
- NIGMS NIH HHS [GM55632, R01 GM055632] Funding Source: Medline
Gap junctions are it unique type of intercellular junction found in most animal cell types. Gap junctions permit the intercellular passage of small molecules and have been implicated in diverse biological processes, such as development, cellular metabolism and cellular growth control. In vertebrates, gap junctions are composed of proteins from the connexin gene family. The majority of connexins are modified posttranslationally by phosphorylation, primarily on serine amino acids; however, phosphotyrosine has also been detected in connexin from cells coexpressing nonreceptor tyrosine protein kinases. Connexins are targeted by numerous protein kinases, of which some have been identified: protein kinase C, mitogen-activated protein kinase, and the v-Src tyrosine protein kinase. Phosphorylation has been implicated in the regulation of a broad variety of connexin processes, such as the trafficking, assembly/disassembly, degradation, as well as the gating of gap junction channels. This review examines the consequences of connexin phosphorylation for the regulation of gap junctional communication. (C) 2000 Academic Press.
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