期刊
BIOCONJUGATE CHEMISTRY
卷 21, 期 8, 页码 1520-1529出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc1001888
关键词
-
类别
资金
- CNRS [ANR-08-BLAN-0114-01]
- Lyon Biopole
- Vaincre la Mucoviscidose
- Region Languedoc-Roussillon
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0114] Funding Source: Agence Nationale de la Recherche (ANR)
Oligonucleotide glycoconjugates with a mannose or galactose core bearing four galactose residues introduced by phosphoramidite chemistry and copper catalyzed azidc alkyne 1,3-dipolar cycloaddition (click chemistry) have been synthesized. A first click reaction allowed the introduction on a solid support of a mannose core on which four pentynyl linkers were introduced using a phosphoramidite derivative. After the elongation of the oligonucleotide, a second click reaction performed either on solid support or in solution allowed the introduction of four galactose azide derivatives. Repeating the phosphoramidite and click chemistries afforded an oligonucleotide glycoconjugate dendrimer bearing 16 galactoses on its periphery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据