期刊
SCIENCE
卷 290, 期 5499, 页码 2137-2140出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.290.5499.2137
关键词
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资金
- NIA NIH HHS [AG16667, R37 AG016667, AG14532] Funding Source: Medline
Aging is genetically determined and environmentally modulated. In a study of Longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult Life-span without a decline in fertility or physical activity. Sequence analysis revealed that the product of this gene, named Indy (for I'm not dead yet), is most closely related to a mammalian sodium dicarboxylate cotransporter-a membrane protein that transports Krebs cycle intermediates. Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly. Excision of the P element resulted in a reversion to normal Life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend Life-span.
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