期刊
FEBS LETTERS
卷 486, 期 3, 页码 270-274出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)02323-1
关键词
tau assembly; phosphorylation; 4-hydroxy-2-nonenal; lipid peroxidation
A correlation between hyperphosphorylation of tau protein and its aberrant assembly into paired helical filaments has lead to suggestions that phosphorylation controls assembly, but lacked a mechanistic basic. In this work, we have found that phosphorylated, but not native, tau protein is able to form polymers after the reaction with 4-hydroxy-2-nonenal, a highly toxic product of lipid peroxidation. Phosphorylation of tau by both proline or non-proline directed kinases, mas able to assemble it into polymers. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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