期刊
ONCOGENE
卷 19, 期 55, 页码 6533-6548出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204034
关键词
Ets; transcription; target genes; expression arrays
资金
- NCI NIH HHS [CA78582] Funding Source: Medline
Ets is a family of transcription factors present in species ranging from sponges to human. All family members contain an approximately 85 amino acid DNA binding domain, designated the Ets domain. Ets proteins bind to specific purine-rich DNA sequences with a core motif of GGAA/T, and transcriptionally regulate a number of viral and cellular genes. Thus, Ets proteins are an important family of transcription factors that control the expression of genes that are critical for several biological processes, including cellular proliferation, differentiation, development, transformation, and apoptosis. Here, we tabulate genes that are regulated by Ets factors and describe past, present and future strategies for the identification and validation of Ets target genes. Through definition of authentic target genes, we will begin to understand the mechanisms by which Ets factors control normal and abnormal cellular processes.
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