期刊
NEUROREPORT
卷 11, 期 18, 页码 4003-4005出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200012180-00020
关键词
bradykinin; B-1 receptor; B-2 receptor knock-out; dorsal root ganglia (DRG); immunohistochemistry; trigeminal nerve ganglia
The bradykinin B-1 receptor is thought to be induced by tissue injury and inflammation. In the present study, we have investigated whether there is a basal expression of B-1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B-1-immunoreactive in rats. Both small and medium-sized DRG neurons were Bi-immunoreactive, suggesting that they are likely to be A delta- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B-1 receptors in the modulation of nociceptive sensory transmission. NeuroReport 11:4003-4005 (C) 2000 Lippincott Williams & Wilkins.
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