期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 10, 期 24, 页码 2765-2768出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00555-2
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A series of new epothilone B and D analogues incorporating fused hetero-aromatic side chains have been prepared. The synthetic strategy is based on olefin 3 as the common intermediate and allows variation of the side-chain structure in a highly convergent and stereoselective manner. Epothilone analogues 1a-d and 2a-d are more potent inhibitors of cancer cell proliferation than the corresponding parent epothilones B or D. (C) 2000 Elsevier Science Ltd. All rights reserved.
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