期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 26, 页码 14376-14381出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.26.14376
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资金
- NIA NIH HHS [AG12282, R01 AG012282] Funding Source: Medline
- NINDS NIH HHS [NS33376, NS35155, R01 NS033376] Funding Source: Medline
The term apoptosis often has been used interchangeably with the term programmed cell death. Here we describe a form of programmed cell death that is distinct from apoptosis by the criteria of morphology, biochemistry, and response to apoptosis inhibitors. Morphologically, this alternative form of programmed cell death appears during development and in same cases of neurodegeneration. Despite its lack of response to caspase inhibitors and Bcl-x(L), we show that this form of cell death is driven by an alternative caspase-9 activity that is Apaf-1-independent. Characterization of this alternative farm of programmed cell death should lead to new insight into cell death programs and their roles in development and degeneration.
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