期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 26, 页码 14737-14741出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.250473597
关键词
testosterone; mounts; intromissions; ejaculation; aggression
资金
- NICHD NIH HHS [HD-05751, R01 HD005751, R37 HD005751] Funding Source: Medline
- NIMH NIH HHS [R01 MH062147, MH62147-01] Funding Source: Medline
Male mice with a knockout of the estrogen receptor (ER)-alpha gene, a ligand-activated transcription factor, showed reduced levels of intromissions and no ejaculations whereas simple mounting behavior was not affected, In contrast, all components of sexual behaviors were intact in male mice lacking the novel ER-beta gene. Here we measure the extent of phenotype in mice that lack both ER-alpha and ER-beta genes (alpha beta ERKO), alpha beta ERKO male mice did not show any components of sexual behaviors, including simple mounting behavior. Nor did they show ultrasonic vocalizations during behavioral tests with receptive female mice, On the other hand, reduced aggressive behaviors of alpha beta ERKO mice mimicked those of single knockout mice of ER-alpha gene (alpha ERKO), They showed reduced levels of lunge and bite aggression, but rarely showed offensive attacks. Thus, either one of the ERs is sufficient for the expression of simple mounting in male mice, indicating a redundancy in function. Offensive attacks, on the other hand, depend specifically on the ER-alpha gene. Different patterns of natural behaviors require different patterns of functions by ER genes.
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