期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 26, 页码 14608-14613出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.26.14608
关键词
-
资金
- NCI NIH HHS [P01 CA80124, P01 CA080124, R35 CA 56591, T32 CA-73479, T32 CA073479] Funding Source: Medline
- NHLBI NIH HHS [P01 HL024136] Funding Source: Medline
The presence of mosaic vessels in which both endothelial cells and tumor cells form the luminal surface has profound implications for metastasis, drug delivery, and antivascular therapy. Yet little is known of the frequency, and thus importance, of mosaic vessels in tumors. Using CD31 and CD105 to identify endothelial cells and endogenous green fluorescent protein labeling of tumor cells, we show that approximate to 15% of pelf used vessels of a colon carcinoma xenografted at two different sites in mice were mosaic vessels having focal regions where no CD31/CD105 immunoreactivity was detected and tumor cells appeared to contact the Vessel lumen. These regions occupied approximate to 25% of the perimeter of the mosaic vessels, or approximate to4% of the total vascular surface area in these colon carcinomas. In addition, we found similar numbers of mosaic vessels in human colon carcinoma biopsies. Our results are consistent with the observation that approximate to 10(6) cells are shed daily per g of tumor. More importantly, our data offer a possible explanation for the antivascular effects of cytotoxic agents and suggest potential strategies for targeting the tumor vasculature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据