期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1498, 期 2-3, 页码 169-173出版社
ELSEVIER
DOI: 10.1016/S0167-4889(00)00093-8
关键词
annexin; acute promyelocytic leukemia; fibrinolysis; antiphospholipid antibody; antiphospholipid syndrome; placenta; endothelium; phospholipid
资金
- NHLBI NIH HHS [HL-61331] Funding Source: Medline
The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family - annexin VI - having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions of the annexins have not been definitively established, two human diseases involving annexin abnormalities ('annexinopathies') have been identified as of the time of writing. Overexpression of annexin II occurs in the leukocytes of a subset of patients having a hemorrhagic form of acute promyelocytic leukemia. Underexpression of annexin V occurs on placental trophoblasts in the antiphospholipid syndrome and in preeclampsia. Also, an animal model has been described in which annexin VII is underexpressed and is associated with disease, but the relevance of this animal model to human disease is not yet understood. Future research is likely to elucidate additional 'annexinopathies'. (C) 2000 Elsevier Science B.V. All rights reserved.
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