期刊
BIOCONJUGATE CHEMISTRY
卷 19, 期 11, 页码 2280-2284出版社
AMER CHEMICAL SOC
DOI: 10.1021/bc8001503
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- Osaka Prefecture University
- Saneyoshi Scholarship Foundation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
Fullerene has a unique structure and notable chemical and physical properties, which have been studied in diverse fields including biological applications. The extremely poor solubility of fullerenes in water limits their usage for biomedical applications. In this study, we synthesized polyamidoamine dendrimers having both beta-cyclodextrin (CD) and poly(ethylene glycol) (PEG) and characterized the resulting dendrimers by H-1 NMR, IR, and gel permeation chromatography. We prepared 2.8 mu M of aqueous fullerene solutions using these dendrimers. The clustering effect of CD and PEG at the surface of the dendrimer might be crucial for the solubilization of fullerene.
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