期刊
DRUG AND ALCOHOL DEPENDENCE
卷 61, 期 1, 页码 55-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0376-8716(00)00123-X
关键词
abuse potential; CL 284,846; drug discrimination; feeding; flumazenil; pharmacokinetics; self-administration; triazolam; zaleplon; zolpidem
资金
- NIDA NIH HHS [R01-DA04133] Funding Source: Medline
Zaleplon is a chemically novel hypnotic that preferentially binds alpha (1)-subunit containing subtypes of the alpha beta gamma configuration of the gamma -aminobutyric acid (GABA)(A) receptor. Zaleplon and the non-subtype-selective hypnotic triazolam occasioned 100% drug-appropriate responding in baboons trained to discriminate lorazepam or pentobarbital from vehicle. Flumazenil shifted the zaleplon generalization gradient at least five-fold to the right. A plasma elimination half-life of 6-8 h for oral 10 mg/kg zaleplon and 0.32 mg/kg triazolam was paralleled by discriminative control for 7 h. Zaleplon maintained self-injection greater than vehicle, as did comparison doses of the similarly selective hypnotic zolpidem and triazolam. Concurrent food-maintained responding increased during self-injection of all three drugs. Preferential binding at this alpha (1)-containing GABA, subtype did not diminish the benzodiazepine (Bzs)-like behavioral effects of zaleplon. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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