Samarium diiodide mediated cascade radical cyclisations-synthesis of the eudesmane tricyclic framework

Radical cascade cyclisation of methylenecyclopropyl cyclohexanone adducts, using samarium diiodide to generate an initial ketyl radical, provide a short route to tricyclic ethers, and the stereochemical outcome can be influenced by the solvent used for the reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.